Epidemiological features of SARS-CoV-2 Omicron infection under new control strategy: a cross-sectional study of the outbreak since December 2022 in Sichuan, China

Background A major shift in the “dynamic zero-COVID” policy was announced by China’s National Health Commission on December 7, 2022, and the subsequent immediate large-scale outbreak of SARS-CoV-2 infections in the entire country has caused worldwide concern. This observational cross-sectional study aimed to describe the epidemiological characteristics of this outbreak in Sichuan, China. Methods All data were self-reported online by volunteers. We described the epidemic by characterizing the infection, symptoms, clinical duration, severity, spatiotemporal clustering, and dynamic features of the disease. Prevalence ratio (PR), Odds ratios (ORs) and adjusted ORs were calculated to analyze the associations between risk factors and infection and the associations of risk factors with clinical severity using log-binomial and multivariable logistic regression models; 95% confidence intervals (CIs) and Wald test results were reported. The prevalence rates and clinical severity among different subgroups were compared using the Chi-square and trend Chi-square tests. Results Between January 6 and 12, 2023, 138,073 volunteers were enrolled in this survey, and 102,645 were infected with COVID-19, holding a prevalence rate of 74.34%; the proportion of asymptomatic infections was 1.58%. Log-binomial regression revealed that the risk of infection increased among those living in urban areas. Multivariable logistic regression analysis showed that female sex, chronic diseases, older age and the fewer doses of vaccine received were associated with an increased risk of severe clinical outcomes after infection. We estimated the mean reproduction number during this pandemic was 1.83. The highest time-dependent reproduction number was 4.15; this number decreased below 1 after 11 days from December 7, 2022. Temporal trends revealed a single peak curve with a plateau pattern of incidence during the outbreak, whereas spatiotemporal clustering analysis showed that the onset in 21 cities in the Sichuan province had four-wave peaks. Conclusions The peak of the first wave of Omicron infection in Sichuan Province had passed and could be considered a snapshot of China under the new control strategy. There were significant increases in the risk of severe clinical outcomes after infection among females, with chronic diseases, and the elderly. The vaccines have been effective in reducing poor clinical outcomes.


Background
COVID-19 has been a global epidemic for three years and has infected approximately 760 million people worldwide and killed 6.8 million people as of March 19, 2023, according to the statistics released by the World Health Organization (WHO) [1].The Omicron variant was first detected in mid-November 2021 in South Africa and was named "variant of concern" by the WHO.Due to its infectivity and immune evasion capacity [2], Omicron has rapidly replaced Delta as the dominant strain worldwide, causing two unprecedented outbreak peaks.The first outbreak occurred in late 2021 and early 2022, mainly in the United States and European countries, whereas the second wave burst occurred in the Western Pacific by the end of 2022, with mainland China as the core region [1].On January 27, 2023, the International Health Regulations (2005) Emergency Committee regarded the ongoing coronavirus disease pandemic as a public health emergency of international concern owing to its capacity to cause substantial damage to health and health systems [3].
Previous studies conducted during the Omicron wave showed that epidemiological characteristics varied in areas owing to different control policies and pre-infection and vaccination patterns in the population.A study reported that the effective reproduction number was 2.19 in the rapid outbreak of the Omicron variant in South Africa, where fewer than one in ten people were fully vaccinated [4].The Real-time Assessment of Community Transmission-1 study estimated that the regional doubling time for Omicron in England in December 2021 ranged from 1.6 to 2.5 days [5], and another study showed that living in urban areas was associated with a higher risk of swab positivity [6].A case-control study in Brazil found that the effectiveness of past infections in preventing reinfection during the Omicron wave was low [7].Moreover, previous studies have found that the Omicron strain is less virulent than the other strains and mainly causes asymptomatic or mild infection [8,9].Early reports have shown that vaccines attenuate COVID-19 symptoms, duration, and viral RNA shedding [10,11].However, the epidemiological and clinical characteristics of Omicron in mainland China during the transition period of the strategy from "dynamic zero-COVID" to "coexistence with the virus" are yet to be elucidated.
By the end of 2022, China implemented the "dynamic zero-COVID" policy for nearly three years since the outbreak of COVID-19 [12], and had > 90% of the Chinese population having had two doses of the COVID-19 vaccine [13].However, the Omicron strain first caused a large local outbreak in Shanghai in April 2022 and continuously caused localized outbreaks in many cities, including Ningbo and Zhuhai [14][15][16], bringing huge challenges to the current policy.China changed its response strategy for COVID-19 on December 7, 2022, by announcing "10 new measures, " which included home isolation or quarantine for individuals with mild symptoms or those who are asymptomatic and the termination of region-wide mass testing [17].Consequently, coupled with a large, susceptible population, the pandemic immediately spread across the country.This study launched a population-based dynamic online cross-sectional survey after the implementation of these 10 measures to fill the gap in regular surveillance.The main objectives of this study are as follows.First, the study described COVID-19 by exploring the infection status of different subgroups in communities and identifying the risk factors for infection.Second, we assessed the clinical features of symptomatic cases, including the occurrence of symptoms, duration, and severity, and detected associations between clinical severity and individual characteristics.Third, the study described the epidemic process by characterizing the spatiotemporal and dynamic features to provide effective information to the Department of Public Health.on the official WeChat public account of the Sichuan CDC and called on staff at all levels in Sichuan province to advertise the survey.Furthermore, some local Internet media outlets, including the Sichuan Daily and Chengdu Publishing also transmitted the survey on their platforms.
All residents of Sichuan Province were recruited as volunteers for the survey, and informed consent was obtained from every participant.The first page of the questionnaire provided an introduction to the survey objective and application of the results.The participants can also proxy-report to their families; therefore, the survey further covers infants, children, and elderly groups who may be out of the reach of our questionnaire.

Outcomes
The following 13 symptoms were investigated: fever, cough, fatigue, headache, expectoration, sore throat, muscle pain, stuffy and runny nose, loss of taste and smell, chills, diarrhea, vomiting, and bloody stool.COVID-19 infection cases referred to participants who were positive for SARS-CoV-2 nucleic acid by RT-PCR or antigen testing by nasopharynx test paper using respiratory specimens or had not yet accepted coronavirus nucleic acid or antigen testing with one or more of the clinical symptoms mentioned above since December 7, 2022.
Cases of infection combined with one or more symptoms were considered symptomatic.The clinical duration was defined as the symptom duration of symptomatic patients who recovered during the survey period.Symptomatic cases, including recovered and unrecovered patients whose symptoms lasted for ≥ 14 days, were analyzed to evaluate the severity of clinical outcomes.Cases were divided into two types: mild-or medium-type, which comprised patients with fewer than five symptoms lasting < 14 days, and severe type, which comprised patients who had ≥ 5 lasting ≥ 14 days.

Statistical analysis
Baseline characteristics are presented as numbers (%) for categorical variables.We stratified the infection rates by geographical location, demographics, vaccination, and smoking characteristics (region, sex, age group, underlying conditions, vaccination, and smoking status).We used log-binomial regression model and calculated prevalence ratio (PR) to estimate the association between region and infection.We calculated the odds ratios (ORs) and adjusted ORs for infection of the other characteristics.The adjustment used a multivariable logistic regression model to analyze the associations between risk factors and infection, and 95% confidence intervals (CIs) and Wald test results were reported.In this regression analysis, all stratification characteristics were included as categorical variables.Multivariable ordinary logistic regression was also employed to investigate the odds of clinical severity between mild-or medium-, and severe cases, adjusting for sex, age, underlying conditions (chronic obstructive pulmonary disease [COPD], diabetes, hypertension, cardiac-cerebral vascular disease, nephropathy, other respiratory diseases, autoimmune diseases [AID], and tumors), vaccination status, and smoking status.The Chi-square and trend chi-square tests were used to compare the infection rates and clinical severity of all subgroups.
We calculated the daily incidence of symptomatic cases in different cities in Sichuan Province and implemented a spatiotemporal cluster analysis to explore different waves in various regions.Based on the assumption that the total population during the survey period was relatively stable, we also estimated the mean reproduction number and time-dependent reproduction number in this pandemic by using "R 0 " package [18].Hierarchical clustering method was used inthe spatiotemporal cluster analysis through "pheatmap" package in R software.The "average" clustering method and "correlation" distance calculation method were applied in the parameter settings [19].We used R version 4.2.1 (The R Foundation for Statistical Computing, Vienna, Austria) for statistical analysis, and P-values < 0.05 were considered statistically significant.

Baseline characteristics
In total, 138,073 participants were enrolled in the survey between January 6 and January 12, 2023.All participants information were collected in the infection risk analysis.However, after applying the exclusion criteria, 97,675 symptomatic cases were included in the spatiotemporal and dynamic features analysis, 86,384 symptomatic cases were included in the symptom and severity analysis, and 58,917 symptomatic cases who had recovered were included in the clinical duration analysis (Fig. 1).
The baseline characteristics stratified by demographic features and vaccination histories are shown in Table 1.Of all participants, 97,810 residents were from urban areas (70.84%), and 40,263 residents were from rural areas (29.16%).More than half of the participants were female (56.95%), and most participants were aged 26-50 years (58.73%).A total of 82.11% of the participants had no chronic diseases before being affected by COVID-19, and most were non-smokers (83.26%).Regarding vaccination history, most participants were administered three vaccine doses (79.1%).

Prevalence rate and risk factors
Among the 138,073 participants, 102,645 were infected by SARS-CoV-2 Omicron including 79,206 cases

Table 1 Demographic characteristics of participants and prevalence rates
$ The differences in prevalence rates in different subgroups were analyzed using the Chi-square and trend chi-square tests a The chronic diseases in this study comprised the following eight diseases: chronic obstructive pulmonary disease (COPD), diabetes, hypertension, cardiac-cerebral vascular disease, nephropathy, other respiratory diseases, autoimmune disease (AID), and tumors b "with chronic diseases" indicates that participants suffered from at least one of the chronic diseases and that multiple presenting conditions were possible

Subgroup
No ).The prevalence rate in women was 77.72%, 11.24% higher than that in men (69.87%), and the prevalence rate in participants with chronic diseases (77.55%) was slightly higher than the average.Across all age categories, the highest incidence rate was in the 26-50-year-old age group (77.88%), followed by the 51-65-year-old age group (75.28%), whereas the remaining groups had a lower-than-average rate.Surprisingly, smokers (64.94%) had a lower prevalence rate than non-smokers (76.23%).Overall, the prevalence rate was higher in those who had been vaccinated (75.51%) than in unvaccinated populations, but the prevalence rate among those who completed four doses of the vaccine (37.02%) was below average.The differences in the prevalence rates of all the stratified characteristics mentioned above were statistically significant (P < 0.001).Table 1 presents the remaining details regarding the participants and infection outcomes.Log-binomial regression analysis showed that the risk of infection was 1.33 (95% CI, 1.32-1.34)times higher for urban residents than for those in rural areas.The results of the multivariable logistic regression analysis showed that female sex (OR, 1.22; 95% CI, 1.19-1.26),chronic diseases (OR, 1.25; 95% CI, 1.20-1.29),and being a nonsmoker (OR, 1.83; 95% CI, 1.77-1.90)were associated with an increased risk of infection.Furthermore, compared with the 13-25-year-old age group, the 0-6-and 7-12-year-old age groups were associated with a reduced risk of causing infections, while the adjusted risk ORs for increasing infection in the 26-50-year-old, 51-64-year-old, and 65-year-old age groups were 1.68 (95% CI, 1.62-1.74),1.48 (95% CI, 1.41-1.55),and 1.24 (95% CI, 1.16-1.33),respectively.For individuals who had not been vaccinated, the completion of four doses of vaccination was associated with a reduced risk, whereas the completion of three doses was associated with an increased risk of infection (OR, 1.15; 95% CI, 1.06-1.25).For more details, see Table 1; Fig. 2.

Clinical manifestation of COVID-19 and risk factors
Of the 102,645 patients in this study, 1617 (1.60%) did not develop any symptoms after infection, and the proportion of asymptomatic infections was 1.58%.By the end of the survey, 58,917 symptomatic cases' clinical symptoms had completely disappeared, with a recovery Fig. 2 Multivariable logistic regression analysis of SARS-CoV-2 infection and clinical severity factors Multivariate logistic analysis was adjusted for sex, age, underlying conditions, vaccination status, and smoking status.Error bars represent 95% CI.Chronic diseases were indicated as individuals suffering from at least one of the following chronic diseases (multiple presenting conditions were possible): COPD, diabetes, hypertension, cardiac-cerebral vascular disease, nephropathy, other respiratory diseases, AID, and tumors; 8 chronic diseases were included herein rate of 60.32%.The longest clinical duration in recovered cases was 36 days, with a median of 11 days (interquartile range, 7-16 days).For more details, please refer to Table 2.As of January 12, 2023, 27,467 symptomatic cases had not recovered, but their symptom duration was ≥ 14 days.Together with the recovered population, 86,384 symptomatic cases were included in the symptom and severity analysis.
Among the 86,384 patients with clinical symptoms, the mean number of symptoms was 6.21, and the five most common symptoms in terms of incidence were cough (83.74%), fever (77.14%), fatigue (67.37%), muscle pain (62.05%), and sore throat (58.41%).There were 47,116 severe cases and 39,268 light (medium) cases.The incidence of severe disease among female patients was 60.26-31.51%higher than that in males and tended to increase with age (p < 0.001).Individuals who had chronic underlying diseases, were not vaccinated, and were non-smokers were more likely to experience severe clinical outcomes, with a prevalence of severe disease of 63.95%, 64.14%, and 57.44%, respectively, in these cases (Table 2).
Multivariable logistic regression analysis showed that female sex (OR, 1.56; 95% CI, 1.51-1.61),having chronic underlying diseases (OR, 1.43; 95% CI, 1.37-1.48),and being a nonsmoker (OR, 2.07; 95% CI, 1.98-2.16)were associated with an increased risk of severe clinical outcomes after infection with COVID-19.Moreover, older age was associated with an increased risk.For example, the risks of severe clinical outcomes in the 26-50-year-old, 51-64-year-old, and 65-year-old age groups were 2.30 times, 2.76 times, and 3.25 times that in the 13-25-year-old age group, respectively.Furthermore, vaccinations were associated with a reduced risk of severe clinical outcomes, and the higher the dose of the vaccine received, the lower the risk of severe clinical outcomes (Table 2; Fig. 2).

Dynamic features and spatiotemporal clustering analysis
There were 83.7 million residents in Sichuan Province in 2022.We estimated the mean reproduction number (R) according to the population and prevalence rate, which was 1.8298 (95% CI,1.8295-1.8300).We estimated the daily time-dependent reproduction number (Rt) for the outbreak period in Sichuan province using daily incidence data, assuming a mean Weibull-distributed generation time of 3.56 days and a standard deviation of 2.28 days [20].Rt was the highest at the beginning of the epidemic, reaching 4.15 (95% CI, 4.06-4.23).Finally, Rt decreased below 1 on December 17, 2022, 11 days after the implementation of the "10 new measures" had been issued (December 7, 2022) (Fig. 3).Moreover, Rt in urban areas (4.10; 95% CI, 4.00-4.19)was lower than that in rural areas (4.51; 95% CI, 4.34-4.68),decreasing below 1 10 days and 14 days after the implementation, respectively.
The results of regional distribution showed that the prevalence rate varied greatly from different regions, with more than 50% of the 21 cities in Sichuan province had a rate above 80%.Temporal trends revealed a single peak curve with a plateau pattern of incidence during the outbreak, and the onset of cases was concentrated between December 12 to December 23, 2022.However, the results of the spatiotemporal clustering analysis showed that onset in the 21 cities in Sichuan Province had four-wave peaks.First, onset in Dazhou, eastern Sichuan peaked on December 8. Second, onset in Chengdu, Suining, and the other 5 cities peaked between December 12 and December 15, 2022.The third wave was in Nanchong; onset in the other seven cities peaked between December 15 and 19.The last wave was in Yibin, and onset in the remaining eight cities peaked between December 18 and 20 (Fig. 4).

Discussion
Since January 20, 2020, COVID-19 has been monitored as a class A communicable disease in China.It requires that all medical institutions and laboratory testing organizations report COVID-19 cases through the National Information System for Disease Control and Prevention within 2 h of detection.However, due to the home isolation of patients with mild or asymptomatic disease and the overloading of medical facilities during the outbreak, we cannot grasp the infection data precisely, which is detrimental to controlling the epidemic.Therefore, we conducted this urgent survey to describe the characteristics of a large-scale outbreak caused by the Omicron variant in Sichuan Province, China after adjusting for the COVID-19 response strategy.
Our Omicron prevalence rate was higher than that of the first wave of Omicron outbreaks in other areas, including South Africa (58% in urban areas by April 2022) [21] and Demark (66% by March 2022) [22], while it was similar to that in Beijing (estimated to be 75.7% on December 22, 2022) and some other major cities (estimated that 60-80% of people were infected) in China [23,24].Given that all over the China had implemented Assuming a mean Weibull-distributed generation time of 3.56 days and standard deviation of 2.28 days, we estimated the Rt using the "R 0 " package and daily case incidence data.The red solid line and pink area represent the point estimates and 95% CI, respectively.The horizontal dashed line represents an Rt of 1, and the vertical dashed line represents the start of 2023.Rt, reproduction number a successful "dynamic zero-COVID" strategy before November 2022, our cumulative prevalence rates were extremely low, and population immunity to SARS-CoV-2 was almost entirely vaccine derived when the Omicron wave began.Therefore,our study could be considered a snapshot of China under the new control strategy, although we only had provincial data.It revealed that the maximum effective reproduction number in Sichuan was higher than that in Beijing (4.15 vs. 3.44, respectively) [23], and the mean reproduction number was slightly higher than that in the first wave of the Omicron epidemic in South Korea (1.83 vs. 1.72, respectively) [25].Nearly 65% of the population was infected in just three weeks, demonstrating that the circulation of the Omicron variant in Sichuan province was more extensive and faster than that in other studies.
The risk of infection among urban residents was 1.33 times higher than that of rural residents; Similarly, in the United Kingdom, the risk of infection among urban residents was 1.24 times that of rural residents [6], which may be related to the high population density and frequent contact among urban populations.Nevertheless, Antonelli et al. suggested that rural areas, especially impoverished areas, are high-risk populations for infection, even if they have been vaccinated [26].Our province has a large population of migrant workers, which leads to the rural population comprising mainly vulnerable groups, including the elderly and children.Moreover, rural areas may have less robust medical capabilities; therefore, we should pay more attention to the Omicron epidemic in these regions and reasonably allocate medical and health resources to reduce the burden of COVID-19 in rural areas [27].
This study found that the rate of asymptomatic infections among infected residents was only 1.58%, which is much lower than that in Zhuhai City in Guangdong Province (76%) [16] and Ningbo City in Zhejiang Province (54.1%) [28].The main reason for this was that the cases were at different stages of disease development when they were detected (i.e., under different response strategies for COVID-19).When the "dynamic zero-COVID" policy was being implemented, mass testing had been applied in response to an outbreak and for disease surveillance among populations at risk, aiming to find people with active infection who are asymptomatic or pre-symptomatic so that early quarantine, tracing, and testing of close contacts can interrupt the spread of COVID-19 [29,30].Therefore, the sensitivity of surveillance is high, resulting in a high proportion of asymptomatic infections.Moreover, according to the outcomes of this study, most participants were deemed positive for COVID-19 based on the presence of symptoms, which is also an important cause of the low proportion of asymptomatic infections reported in this study.
Cough, fever, and fatigue were the most common clinical symptoms among symptomatic cases, which differs The light-orange bar chart represents the daily incidence of SARS-CoV-2 during this provincial outbreak.We conducted a spatiotemporal clustering analysis of 21 cities in Sichuan Province using daily incidence data from different regions, as shown in the heat map below from the initial results of studies conducted in South Africa, the United Kingdom, and other countries [31][32][33].Their reports also listed runny nose and headache as the most common symptoms, which may be related to the different characteristics of the Omicron substrain, including ethnicity, previous COVID-19 infection, and vaccination status of the population [7].The mean number of symptoms was very similar to the findings of Thompson et al. [34], but the clinical duration herein was shorter than that reported by them (12.3 d).
Similar to many previous studies [35][36][37], we found that chronic diseases and older age were associated with an increased risk of both incidence and poor COVID-19 clinical outcomes.For example, the United Kingdom and Italy analyzed COVID-19 cases and demonstrated that older age was associated with poorer outcomes [38,39].This again proved that increasing vaccination rates among the elderly and populations with underlying conditions was the key to containing COVID-19 and reducing the disease burden of morbidity and mortality.However, we found that women had a higher prevalence rate and incidence of severe clinical outcomes than men, which was contrary to the results of most other studies [40,41].Research in Canada had the same result as ours: Although the absolute number of COVID-19 cases was higher for females, they had a lower COVID-19 incidence rate after excluding the high-risk populations; more specifically, healthcare workers and long-term care residents, which are predominantly females [42].Therefore, the true risk of sex during the Omicron outbreak needs to be further analyzed in depth in relation to age and occupation.Accordingly, we cannot draw any conclusions from the current data.
Interestingly, we found that smokers had a lower risk of both infection and severe clinical outcomes.The role played by smoking in COVID-19 infection has remained an open debate since the pandemic.Lippi G et al. published two articles in the European Journal of Internal Medicine to discuss this paradox.They summarized some large cohort studies or meta-analyses published on this topic in recent years [43][44][45] and considered that a simple conclusion that current smoking increases the risk of clinical deterioration in COVID-19 is largely unsupported according to the currently available scientific evidence [46,47].Simons et al. found that current smokers had a lower risk of SARS-CoV-2 infection than never smokers [43], and Chen et al. revealed that current smokers had an over 30% lower risk of COVID-19-related death (hazard ratio (HR), 0.57; 95%CI, 0.49-0.67)[44].Both of the results were the same with us.In Thailand, Papadopoulos et al. conducted in-depth studies on the mechanisms of smoking pertaining to COVID-19 and concluded that environmental and novel genetic mechanisms may independently or jointly contribute to transient and serendipitous SARS-CoV-2 protection [48].Nevertheless, the unfavorable consequences of cigarette smoking are paramount and indisputable, the effects are short-lived and gradually become irrelevant.Smoking is still the most potent common oxidant challenge encountered by the human respiratory tract that damages the arterial endothelium and wall, ultimately predisposing patients to a lethal COVID-19 disease course.Since the introduction of the Omicron variant worldwide, the effect of vaccination against the original strain on infection has attracted much attention [7,49].We found that, compared with the unvaccinated population, being vaccinated ≤ 3 times for COVID-19 had no significant effect on preventing infection but had a good effect on reducing the severity of clinical symptoms.It is generally recognized that the 3 dosages of vaccination have limited protective effect against Omicron.For example, Accorsi Ek et al. found that receipt of 3 doses of mRNA vaccine, relative to being unvaccinated and to receipt of 2 doses, was associated with protection against both the Omicron and Delta variants, although the higher odds ratios for Omicron suggest less protection for Omicron than for Delta [49].A study in Hong Kong found that 100 days after receiving three or four doses of inactivated COVID-19 vaccine, the vaccine's protective effect decayed to 6% and 11% of its original level, respectively [50].However, Angel Paternina-Caicedo and her team found that non-mRNA vaccines showed little or no sustained protection against symptomatic COVID-19 during Omicron predominant periods in adult populations and the boosters of non-mRNA vaccines (i.e., CoronaVac, ChAdOx1, and Ad26.COV2.S) did not show protection against symptomatic Omicron during the entire follow-up period [51].
However, completion of the four doses of the COVID-19 vaccination significantly prevented infection and severe illnesses.It may result in that the four-dose COVID-19 vaccine strategy is a reinforced vaccine strategy specifically developed against the Omicron variant.The general population in China began to receive it on December 13 (i.e., during the epidemic period); therefore, better immune effects were expected.

Limitations
However, this study had some limitations.First, this survey was conducted online, and participants were biased toward highly educated adults who were proficient in using the internet, with higher participation from females and lower coverage of infants, young children, and the elderly.The age structure of the surveyed population differed from that of Sichuan Province, leading to information bias.Second, although the total population was large, the information obtained was self-reported.Particularly, for cases defined based on clinical symptoms, the survey may have included a small number of individuals with fever and cough caused by other respiratory viruses, thereby reducing the reliability of the survey results.Third, owing to the lack of data on hospitalization and mortality cases during the outbreak, the disease burden of COVID-19 was inadequately seized.Fourth, for the evaluation of COVID-19 vaccine effectiveness, only the number of COVID-19 vaccine doses received by residents was surveyed, and detailed information on the type and timing of the COVID-19 vaccine received was not obtained.Therefore, extrapolation of our conclusions about vaccine effects should be cautious.Further research is warranted to identify appropriate correlates of protection for inactivated COVID-19 vaccines.

Conclusions
The peak of the first wave of Omicron infection in Sichuan Province had passed and could be considered a snapshot of China under the new control strategy.Asymptomatic infections were rare in this large-scale outbreak and living in urban areas was associated with a higher risk of infection.Furthermore, there is a significant increase in the risk of severe clinical outcomes among females, those with chronic diseases, and the elderly.The vaccines have been effective in reducing poor clinical outcomes.What's more, routine surveillance systems must be improved and optimized under the extreme conditions of highly infectious diseases.

Fig. 1
Fig. 1 Flow diagram of the participant inclusion and exclusion criteria for defining study cohorts for analysis

Fig. 4
Fig. 4 Temporal and Spatiotemporal dynamics of SARS-CoV-2 cases in Sichuan between December 7, 2022, and January 12, 2023 AbbreviationsCDCCenters for Disease Control and Prevention OR Odds ratio CI Confidence interval COPD Chronic obstructive pulmonary disease AID Autoimmune diseases

Table 2
Clinical characteristics of symptomatic cases of COVID-19 in Sichuan province$ Differences in the proportion of different clinical outcomes were analyzed using the Chi-square and trend chi-square tests a Clinical duration refers to symptom duration, which indicates symptomatic cases that have already recovered.However, 58,917 cases were involved in the clinical duration analysis